HIV Disrupts Antimalarial Protective Effects of Pregnancy
نویسندگان
چکیده
منابع مشابه
The safety of antimalarial drugs in pregnancy.
Alternative drugs to chloroquine are required to prevent the deleterious effects of malaria in pregnancy. Fear of potential toxicity has limited antimalarial drug use in pregnancy. Animal toxicity studies have documented teratogenicity when antimalarials are administered at high dosages. Excepting the tetracyclines, there is no evidence to suggest that, at standard dosages, any of the antimalar...
متن کاملBilayer Effects of Antimalarial Compounds
Because of the perpetual development of resistance to current therapies for malaria, the Medicines for Malaria Venture developed the Malaria Box to facilitate the drug development process. We tested the 80 most potent compounds from the box for bilayer-mediated effects on membrane protein conformational changes (a measure of likely toxicity) in a gramicidin-based stopped flow fluorescence assay...
متن کاملMobile phone exposure during pregnancy disrupts learning and memory in rat offsprings
Abstract Introduction: Mobile phones create high-frequency electromagnetic fields around them when in use. The close proximity of mobile phones to the user’s head leads to the absorption of part of the electromagnetic waves into the head and the brain. Methods: We have elucidated the alteration in cognitive function of the male and female offspring rats, which were exposed to chronic mobi...
متن کاملCircadian Clock Mutation Disrupts Estrous Cyclicity and Maintenance of Pregnancy
Classic experiments have shown that ovulation and estrous cyclicity are under circadian control and that surgical ablation of the suprachiasmatic nuclei (SCN) results in estrous acyclicity in rats. Here, we characterized reproductive function in the circadian Clock mutant mouse and found that the circadian Clock mutation both disrupts estrous cyclicity and interferes with the maintenance of pre...
متن کاملPregnancy in HIV-Positive Patients: Effects on Vaginal Flora
A high proportion of HIV-infected pregnant women present pathogenic organisms in their lower genital tract. This has been associated with the development of postpartum morbility, HIV transmission to the partner and offspring, and other gynaecological conditions, such as cervical dysplasia or cancer. Vaginal flora alterations can range from 47% in Western countries to 89% in Africa in pregnant H...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Microbe Magazine
سال: 2007
ISSN: 1558-7452,1558-7460
DOI: 10.1128/microbe.2.479.1